Studying melanin and lipofuscin in RPE cell culture models
نویسندگان
چکیده
منابع مشابه
Studying melanin and lipofuscin in RPE cell culture models.
The retinal pigment epithelium contains three major types of pigment granules; melanosomes, lipofuscin and melanolipofuscin. Melanosomes in the retinal pigment epithelium (RPE) are formed during embryogenesis and mature during early postnatal life while lipofuscin and melanolipofuscin granules accumulate as a function of age. The difficulty in studying the formation and consequences of melanoso...
متن کاملUnderstanding RPE lipofuscin.
In the Research Highlight article titled ‘‘Rethinking A2E,’’ Smith et al. offer interpretations of the recent paper by Ablonczy et al., titled ‘‘Lack of Correlation Between the Spatial Distribution of A2E and Lipofuscin Fluorescence in the Human Retinal Pigment Epithelium.’’ Readers will benefit from further discussion. Although not acknowledged by Smith et al., RPE lipofuscin consists of multi...
متن کاملUnderstanding RPE Lipofuscin.
In the recent paper by Allingham et al., fundus autofluorescence (AF) was studied in relation to progression of geographic atrophy (GA) in age-related macular degeneration (AMD), a subject of intense ongoing interest. The primary conclusion was that rim area focal hyperautofluorescence (RAFH) was positively correlated with GA progression rate (r 1⁄4 0.49, P < 0.001), consistent with Bearelly et...
متن کاملFundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration
Genes that increase susceptibility to age-related macular degeneration (AMD) have been identified; however, since many individuals carrying these risk alleles do not develop disease, other contributors are involved. One additional factor, long implicated in the pathogenesis of AMD, is the lipofuscin of retinal pigment epithelium (RPE). The fluorophores that constitute RPE lipofuscin also serve ...
متن کاملRetinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.
Optical measurements of the pigments of the retinal pigment epithelium (RPE) and choroid were made on 38 human autopsy eyes of both blacks and whites, varying in age between 2 wk and 90 yr old. Lipofuscin in melanin-bleached RPE was measured as fluorescence at 470 mm following excitation at 365 nm and was found to be proportional to fluorescence measured at 560 nm in unbleached tissue. Transmis...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2014
ISSN: 0014-4835
DOI: 10.1016/j.exer.2014.01.016